Characteristics of HPV infection among 4 084 gynecological outpatients

Abstract

Objective To investigate the distribution of human papillomavirus (HPV) subtypes in women with different age and analyze the relationship between HPV and cervical lesions. Methods A cross-sectional study was conducted on 4 084 patients who underwent colposcopy for pathological examination and HPV genotyping assay in our hospital from January 2015 to June 2020. The patients are classified into 5 groups in respect to the age and 6 groups (the cervicitis, CIN Ⅰ, CIN Ⅱ, CIN Ⅲ, cervical carcinoma in situ and cervical cancer groups) in respect to pathological results respectively. Chi-square test was used to analyze the difference among groups mentioned and to analyze the overall situation of HPV infection, the positive rate of detection of HPV, subtype distribution, infection with single and multiple HPV genotypes among different age groups. Spearman's correlation analysis was used to analyze distribution characteristics of HPV subtypes infection and cervical lesion among different age groups. Results The positive rate of HPV was 93.24% (3808/4 084) different in 5 age groups(Chi-square=11.400 P=0.022). The single subtype infection accounted for 64.67%, and the difference of single subtype infection and multiple subtypes infection was statistically significant among different age groups(Chi-square=70.736, P < 0.001). HPV16(31.88%)、HPV52(25.20%)、HPV58 (14.57%)、HPV18 (11.12%)and HPV51(7.81%)were the top 5 among 23 subtypes of HPV detected. The distribution difference of positive rate of HPV was statistically significant among different lesion groups (P < 0.05). In the cervical cancer group, most patients were infected with HPV16, HPV 18, HPV 52, HPV 58, and HPV 33. Spearman's correlation analysis showed there was a significant correlation between age and cervical lesions (r=0.051, P=0.001). Positive rate of cervical cancer were 0.29% in age 18~29, 1.08% in 30~39, 3.52% in age 40~49, 4.09% in age 50~59 and 10.37% in age 60~82. Conclusion HPV16, HPV 52, HPV 58 and HPV 18 are the most prevalent subtypes among 4 084 patients. HPV16 and HPV18 are relevant with cervical cancer. The risk of cervical cancer is significantly higher for women older than 40. The positive rate of cervical cancer increases with the age.

Keywords

• human papillomavirus
• genotype
• cervical lesion
• cervical cancer