DegP Initiates Regulated Processing of Filamentous Hemagglutinin in Bordetella bronchiseptica

Richard M. Johnson; Zachary M. Nash; Margaret R. Dedloff; John C. Shook; Peggy A. Cotter

doi:10.1128/mBio.01465-21

mBio (Jun 2021)

DegP Initiates Regulated Processing of Filamentous Hemagglutinin in Bordetella bronchiseptica

Richard M. Johnson,
Zachary M. Nash,
Margaret R. Dedloff,
John C. Shook,
Peggy A. Cotter

Affiliations

Richard M. Johnson: ORCiD; Department of Microbiology and Immunology, School of Medicine, University of North Carolina—Chapel Hill, Chapel Hill, North Carolina, USA
Zachary M. Nash: Department of Microbiology and Immunology, School of Medicine, University of North Carolina—Chapel Hill, Chapel Hill, North Carolina, USA
Margaret R. Dedloff: Department of Microbiology and Immunology, School of Medicine, University of North Carolina—Chapel Hill, Chapel Hill, North Carolina, USA
John C. Shook: Department of Microbiology and Immunology, School of Medicine, University of North Carolina—Chapel Hill, Chapel Hill, North Carolina, USA
Peggy A. Cotter: ORCiD; Department of Microbiology and Immunology, School of Medicine, University of North Carolina—Chapel Hill, Chapel Hill, North Carolina, USA

DOI: https://doi.org/10.1128/mBio.01465-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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Two-partner secretion (TPS) systems are broadly distributed among Gram-negative bacteria and play important roles in bacterial pathogenesis. FhaB-FhaC is the prototypical member of the TPS family and we here identified the protease that initiates a processing cascade that controls FhaB function.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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