Detection of Active Mammalian GH31 α‑Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

• Jianbing Jiang,
• Chi-Lin Kuo,
• Liang Wu,
• Christian Franke,
• Wouter W. Kallemeijn,
• Bogdan I. Florea,
• Eline van Meel,
• Gijsbert A. van der Marel,
• Jeroen D. C. Codée,
• Rolf G. Boot,
• Gideon J. Davies,
• Herman S. Overkleeft,
• Johannes M. F. G. Aerts

Affiliations

Jianbing Jiang

Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, The Netherlands

Chi-Lin Kuo

Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands

Liang Wu

Department of Chemistry, University of York, U.K.

Christian Franke

Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, The Netherlands

Wouter W. Kallemeijn

Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands

Bogdan I. Florea

Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, The Netherlands

Eline van Meel

Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands

Gijsbert A. van der Marel

Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, The Netherlands

Jeroen D. C. Codée

Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, The Netherlands

Rolf G. Boot

Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands

Gideon J. Davies

Department of Chemistry, University of York, U.K.

Herman S. Overkleeft

Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, The Netherlands

Johannes M. F. G. Aerts

Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands