Obtaining and Investigation of Polymer Compositions Based on Poly-3-Hydroxybutyrate

Abstract

The morphology, surface properties and biocompatibility of mixtures of poly-3-hydroxybutyrate with poly-ε-caprolactone, poly-DL-lactide, polyethylene glycol and starch were studied. Differences in the film surface microstructure were revealed using electron microscopy: composites of P(3HB) with PEG and PCL had a more coarse-pored surface compared to the pure P(3HB). Addition of PEG led to a significant increase in surface hydrophilicity. In the culture of mouse NIH 3T3 fibroblasts the following effects were observed: the absence of cytotoxic effect, the presence of cell adhesion and proliferation. Thus, the biocompatibility of the studied composites and their suitability for production of polymer products for cellular technologies was shown

Keywords

• biopolymers
• polyhydroxybutyrate
• polycaprolactone
• polylactide
• polyethylene oxide
• starch
• biocompatibility