Comparative analysis of the results semen examination in patients with azoospermia caused by cystic fibrosis and congenital bilateral aplasia of vas deferens syndrome

Abstract

The study objective is to compare the results of semen examination in patients with the congenital bilateral aplasia of vas deferens (CBAVD) syndrome and patients with cystic fibrosis.Materials and methods. Ninety-one patients with azoospermia were included in the study, 38 of them with CBAVD and 53 with cystic fibrosis. There were no significant differences in semen parameters (volume, viscosity and pH of the seminal fluid, the count of sperm and leukocytes) between the patients’ groups. In most samples of the ejaculate sediment, investigated by quantitative karyological analysis, spermatozoa and/or immature germ cells were found, indicating a partial preservation of patency of the vas deferens in most of CBAVD patients, also as azoospermic men with CF. Obtained data refute the generally accepted opinion about the absence of vas deferens in these patients, therefore, it is necessary to revise the terminology and further study the pathogenesis of abnormalities of vas deferens and seminal vesicles.

Keywords

• cystic fibrosis
• cbavd syndrome
• male infertility
• obstructive azoospermia
• vas deferens
• seminal vesicles
• spermatogenesis
• sperm
• immature germ cells
• ejaculate