Drug-Drug Interactions at Organic Cation Transporter 1

Shiwei Zhou; Shiwei Zhou; Shiwei Zhou; Sujuan Zeng; Yan Shu; Yan Shu

doi:10.3389/fphar.2021.628705

Frontiers in Pharmacology (Feb 2021)

Drug-Drug Interactions at Organic Cation Transporter 1

Shiwei Zhou,
Shiwei Zhou,
Shiwei Zhou,
Sujuan Zeng,
Yan Shu,
Yan Shu

Affiliations

Shiwei Zhou: Key Laboratory of Oral Medicine, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, China
Shiwei Zhou: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, MD, United States
Shiwei Zhou: Department of Thyroid Surgery, The Second Xiangya Hospital, Central South University, Hunan, China
Sujuan Zeng: Key Laboratory of Oral Medicine, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, China
Yan Shu: Key Laboratory of Oral Medicine, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, China
Yan Shu: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, MD, United States

DOI: https://doi.org/10.3389/fphar.2021.628705
Journal volume & issue: Vol. 12

Abstract

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The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

About the journal

Abstract

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