Frontiers in Cellular and Infection Microbiology (Nov 2021)

Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species

  • Kai Nie,
  • Kai Nie,
  • Kejia Ma,
  • Kejia Ma,
  • Weiwei Luo,
  • Weiwei Luo,
  • Zhaohua Shen,
  • Zhaohua Shen,
  • Zhenyu Yang,
  • Zhenyu Yang,
  • Mengwei Xiao,
  • Mengwei Xiao,
  • Ting Tong,
  • Ting Tong,
  • Yuanyuan Yang,
  • Yuanyuan Yang,
  • Xiaoyan Wang,
  • Xiaoyan Wang

DOI
https://doi.org/10.3389/fcimb.2021.757718
Journal volume & issue
Vol. 11

Abstract

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Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent intestinal inflammation and maintain energy homeostasis by producing metabolites. Evidence shows that this bacterium contributes to various diseases, such as inflammatory bowel disease, type 2 diabetes mellitus, antiphospholipid syndrome, and atherosclerosis. This review reveals the potential therapeutic role of R. intestinalis in human diseases. Patients with inflammatory bowel disease exhibit significant changes in R. intestinalis abundance, and they may benefit a lot from modulations targeting R. intestinalis. The data reviewed here demonstrate that R. intestinalis plays its role in regulating barrier homeostasis, immune cells, and cytokine release through its metabolite butyrate, flagellin and other. Recent advancements in the application of primary culture technology, culture omics, single-cell sequencing, and metabonomics technology have improved research on Roseburia and revealed the benefits of this bacterium in human health and disease treatment.

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