Nature Communications (Apr 2020)

Molecular basis for assembly of the shieldin complex and its implications for NHEJ

  • Ling Liang,
  • Jiawen Feng,
  • Peng Zuo,
  • Juan Yang,
  • Yishuo Lu,
  • Yuxin Yin

DOI
https://doi.org/10.1038/s41467-020-15879-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions to suppress the DNA termini nucleolytic resection during non-homologous end joining (NHEJ). Here the authors present the crystal structure of the SHLD3-REV7-SHLD2 ternary complex revealing insights into the mechanism of the complex.