The Effects of Acute Exercise on RANKL/RANK/OPG Pathway and Bone Metabolic Markers in Healthy College Female

Abstract

PURPOSE The purpose of this study was to examine the effects of acute exercise with difference Intensitis on RANKL/RANK/OPG pathway and bone metabolic markers in healthy college female. METHODS Ten healthy college females (aged 21.5±1.84 years; VO2max 37.69±3.74 mL/kg/min) examined bone metabolic markers and RANKL/RANK/OPG pathway responses to acute exercise of high (80% VO2max; HIGH group), moderate (60% VO2max; MOD group) intensity with a treadmill ergometer, and sedentary rest (CON group) in a randomized, cross-over repeated measures design. The serum concentrations of bone metabolic markers such as OC and CTx, and RANKL, OPG measured at before, immediately after and then recovery 90 minutes after exercise. mRNA expressions of RANKL and RANK, OPG from PBMC were also measured at same times. RESULTS There were no significant differences in the serum OC, CTx concentrations among different exercise intensities (CON, MOD, HIGH) and over time (before, after and recovery) (NS). Also no significant differences were found in the serum RANKL, OPG concentrations and all RANKL/RANK/OPG pathway mRNA expression (NS). CONCLUSIONS These results suggested that acute exercise does not disrupted the RANKL/RANK/OPG pathway and bone metabolic markers in a short time. A follow-up studies are required that tracking for long term from 3 days to 1 week.

Keywords

• acute exercise
• healthy college female
• rankl
• rank
• opg