Design of a self-driven probiotic-CRISPR/Cas9 nanosystem for sono-immunometabolic cancer therapy

Jifeng Yu; Bangguo Zhou; Shen Zhang; Haohao Yin; Liping Sun; Yinying Pu; Boyang Zhou; Yikang Sun; Xiaolong Li; Yan Fang; Lifan Wang; Chongke Zhao; Dou Du; Yan Zhang; Huixiong Xu

doi:10.1038/s41467-022-35580-z

Nature Communications (Dec 2022)

Design of a self-driven probiotic-CRISPR/Cas9 nanosystem for sono-immunometabolic cancer therapy

Jifeng Yu,
Bangguo Zhou,
Shen Zhang,
Haohao Yin,
Liping Sun,
Yinying Pu,
Boyang Zhou,
Yikang Sun,
Xiaolong Li,
Yan Fang,
Lifan Wang,
Chongke Zhao,
Dou Du,
Yan Zhang,
Huixiong Xu

Affiliations

Jifeng Yu: Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University
Bangguo Zhou: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Shen Zhang: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Haohao Yin: Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University
Liping Sun: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Yinying Pu: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Boyang Zhou: Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University
Yikang Sun: Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University
Xiaolong Li: Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University
Yan Fang: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Lifan Wang: Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University
Chongke Zhao: Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University
Dou Du: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Yan Zhang: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University
Huixiong Xu: Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University

DOI: https://doi.org/10.1038/s41467-022-35580-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Recently, strategies based on the integration of nanotechnology with microbial carriers have been proposed for cancer therapy. Here the authors report the design of an ultrasound-controlled CRISPR/Cas9 gene editing system for IDO1 silencing compounded with the probiotic Lactobacillus rhamnosus GG, showing the induction of anti-tumor immune responses in preclinical cancer models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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