Nature Communications (Jun 2020)
The integrated genomic and epigenomic landscape of brainstem glioma
- Lee H. Chen,
- Changcun Pan,
- Bill H. Diplas,
- Cheng Xu,
- Landon J. Hansen,
- Yuliang Wu,
- Xin Chen,
- Yibo Geng,
- Tao Sun,
- Yu Sun,
- Peng Zhang,
- Zhen Wu,
- Junting Zhang,
- Deling Li,
- Yang Zhang,
- Wenhao Wu,
- Yu Wang,
- Guangyu Li,
- Jie Yang,
- Xiaoyue Wang,
- Ce Xu,
- Sizhen Wang,
- Matthew S. Waitkus,
- Yiping He,
- Roger E. McLendon,
- David M. Ashley,
- Hai Yan,
- Liwei Zhang
Affiliations
- Lee H. Chen
- Department of Pathology, Duke University Medical Center
- Changcun Pan
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Bill H. Diplas
- Department of Pathology, Duke University Medical Center
- Cheng Xu
- Department of Pathology, Duke University Medical Center
- Landon J. Hansen
- Department of Pathology, Duke University Medical Center
- Yuliang Wu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Xin Chen
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Yibo Geng
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Tao Sun
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Yu Sun
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Peng Zhang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Zhen Wu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Junting Zhang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Deling Li
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Yang Zhang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Wenhao Wu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Yu Wang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Guangyu Li
- Genetron Health (Beijing) Co. Ltd
- Jie Yang
- Genetron Health (Beijing) Co. Ltd
- Xiaoyue Wang
- State Key Laboratory of Medical Molecular Biology, Center for Bioinformatics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College
- Ce Xu
- Genetron Health (Beijing) Co. Ltd
- Sizhen Wang
- Genetron Health (Beijing) Co. Ltd
- Matthew S. Waitkus
- Department of Pathology, Duke University Medical Center
- Yiping He
- Department of Pathology, Duke University Medical Center
- Roger E. McLendon
- Department of Pathology, Duke University Medical Center
- David M. Ashley
- Preston Robert Tisch Brain Tumor Center, Duke University Medical Center
- Hai Yan
- Department of Pathology, Duke University Medical Center
- Liwei Zhang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- DOI
- https://doi.org/10.1038/s41467-020-16682-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Brainstem gliomas are heterogenous in terms of clinical outcome and disease etiology. Here, the authors present a genetic and epigenetic landscape of brainstem gliomas, finding distinct epigenetic clusters associated with unique genetic and clinical profiles.
