Nature Communications (Oct 2016)

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

  • Jiho Jang,
  • Sangjun Park,
  • Hye Jin Hur,
  • Hyun-Ju Cho,
  • Inhwa Hwang,
  • Yun Pyo Kang,
  • Isak Im,
  • Hyunji Lee,
  • Eunju Lee,
  • Wonsuk Yang,
  • Hoon-Chul Kang,
  • Sung Won Kwon,
  • Je-Wook Yu,
  • Dong-Wook Kim

DOI
https://doi.org/10.1038/ncomms13129
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

Read online

The mechanism underlying neuroinflammation in X-linked adrenoleukodystrophy (ALD) is poorly understood. Here authors identify aberrant production of 25-hydroxycholesterol (25-HC) in ALD patient-derived cells, and show that 25-HC mediates neuroinflammation via activating the NLRP3 inflammasome.