Antiretroviral Therapies for Human Immunodeficiency Virus and Liver Disease: Challenges and opportunities

Abstract

Summary: The post antiretroviral therapy (ART) era for human immunodeficiency virus (HIV) infection resulted in a dramatically increased proportion of deaths attributed to liver-related causes in patients with HIV treated with ART. Additionally, as patients become older as a result of effective ART, liver-related conditions and application of safe therapies are now major concerns in the setting of HIV infection.

Keywords

• Liver fibrosis
• Nucleoside reverse transcriptase inhibitors (NRTIs)
• Protease inhibitors (PIs)
• Nonalcoholic fatty liver disease (NAFLD)
• Nonalcoholic steatohepatitis (NASH)
• Coinfections