Nature Communications (Feb 2023)
Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle
- Nika Rajabian,
- Izuagie Ikhapoh,
- Shahryar Shahini,
- Debanik Choudhury,
- Ramkumar Thiyagarajan,
- Aref Shahini,
- Joseph Kulczyk,
- Kendall Breed,
- Shilpashree Saha,
- Mohamed Alaa Mohamed,
- Susan B. Udin,
- Aimee Stablewski,
- Kenneth Seldeen,
- Bruce R. Troen,
- Kirkwood Personius,
- Stelios T. Andreadis
Affiliations
- Nika Rajabian
- Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York
- Izuagie Ikhapoh
- Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York
- Shahryar Shahini
- Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York
- Debanik Choudhury
- Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York
- Ramkumar Thiyagarajan
- Division of Geriatrics and Palliative Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo and Research Service, Veterans Affairs Western New York Healthcare System
- Aref Shahini
- Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York
- Joseph Kulczyk
- Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York
- Kendall Breed
- Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York
- Shilpashree Saha
- Department of Biomedical Engineering, University at Buffalo
- Mohamed Alaa Mohamed
- Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York
- Susan B. Udin
- Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo
- Aimee Stablewski
- Gene Targeting and Transgenic Shared Resource, Roswell Park Comprehensive Cancer Institute
- Kenneth Seldeen
- Division of Geriatrics and Palliative Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo and Research Service, Veterans Affairs Western New York Healthcare System
- Bruce R. Troen
- Division of Geriatrics and Palliative Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo and Research Service, Veterans Affairs Western New York Healthcare System
- Kirkwood Personius
- Department of Rehabilitation Science, School of Public Health and Health Professions, University at Buffalo
- Stelios T. Andreadis
- Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York
- DOI
- https://doi.org/10.1038/s41467-023-36483-3
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Aged myoblasts suffer from impaired glycolysis and insulin resistance, but increase methionine catabolism, possibly to meet energetic demands. Here, authors show that inhibiting methionine metabolism via NANOG reprogramming or MAT2A inhibition restores the function and regeneration capacity of aged muscle.
