Management of endo-perio lesion with autologous stem cell therapy

Abstract

The objective of periodontal therapy is the regeneration of tooth-supporting tissues. Various treatment modalities, such as the use of bone grafting materials, guided tissue regeneration, and delivery of enamel matrix derivatives or growth factors, are applied with large variability in regenerative outcomes. However, a case report was done by utilization of autologous dental pulp stem cells and periodontal ligament stem cell niches in the treatment of bone loss associated with endodontically and periodontally involved teeth. An autologous periodontal ligament stem cells niche adherent to the root and dental pulpal stem cells from dental pulp directly into the selected osseous defect following extraction of the impacted tooth in the same patient. The results of this case reported that the dental pulpal stem cells and periodontal ligament stem cells niche with gelatin sponge resulted in a significant amount of bone fill and reduction in probing pocket depth.

Keywords

• apicoectomy
• gelatin
• mesenchymal stem cells
• periodontal pocket
• stem cell niche