Fifty years of BMT: risk stratification, donor matching, and stem cell collection for transplantation

Amandeep Salhotra; Shan Yuan; Haris Ali

doi:10.3389/fonc.2023.1196564

Frontiers in Oncology (Aug 2023)

Fifty years of BMT: risk stratification, donor matching, and stem cell collection for transplantation

Amandeep Salhotra,
Shan Yuan,
Haris Ali

Affiliations

Amandeep Salhotra: Department of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, United States
Shan Yuan: Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, City of Hope National Medical Center, Duarte, CA, United States
Haris Ali: Department of Hematology and Hematopoietic Cell Transplantation (HCT), City of Hope National Medical Center, Duarte, CA, United States

DOI: https://doi.org/10.3389/fonc.2023.1196564
Journal volume & issue: Vol. 13

Abstract

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In this review, we discuss recipient risk assessment for allo-HCT regarding comorbidities present at baseline to predict non relapse mortality. We further reviewed the incorporation of remission status and cytogenetic risk prior to allograft transplantation to predict relapse rates for hematologic malignancies. HCT-CI and DRI are tools available to physicians to assess the risk–benefit of allo-HCT in patients referred for transplantation. Next, we discuss our algorithm for donor selection and criteria for donor selection in case matched donors are not available. Finally, we discuss our approach for stem cell mobilization, especially in donors failing G-CSF, and our approach for the use of plerixafor and data supporting its use.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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