Disengaging spinal afferent nerve communication with the brain in live mice

Melinda A. Kyloh; Timothy J. Hibberd; Joel Castro; Andrea M. Harrington; Lee Travis; Kelsi N. Dodds; Lukasz Wiklendt; Stuart M. Brierley; Vladimir P. Zagorodnyuk; Nick J. Spencer

doi:10.1038/s42003-022-03876-x

Communications Biology (Sep 2022)

Disengaging spinal afferent nerve communication with the brain in live mice

Melinda A. Kyloh,
Timothy J. Hibberd,
Joel Castro,
Andrea M. Harrington,
Lee Travis,
Kelsi N. Dodds,
Lukasz Wiklendt,
Stuart M. Brierley,
Vladimir P. Zagorodnyuk,
Nick J. Spencer

Affiliations

Melinda A. Kyloh: Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University
Timothy J. Hibberd: Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University
Joel Castro: Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University
Andrea M. Harrington: Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University
Lee Travis: Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University
Kelsi N. Dodds: Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University
Lukasz Wiklendt: Discipline of Human Physiology, College of Medicine and Public Health, Flinders University
Stuart M. Brierley: Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University
Vladimir P. Zagorodnyuk: Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University
Nick J. Spencer: Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University

DOI: https://doi.org/10.1038/s42003-022-03876-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

A surgical method in mice can selectively remove dorsal root ganglia (DRG) at specific spinal levels without interfering with other nerves, providing insight on thoracolumbar vs. lumbosacral DRG contributions to pain signalling and behaviour.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal