Nature Communications (Nov 2017)
Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs
- Ivan Vannini,
- Petra M. Wise,
- Kishore B. Challagundla,
- Meropi Plousiou,
- Mirco Raffini,
- Erika Bandini,
- Francesca Fanini,
- Giorgia Paliaga,
- Melissa Crawford,
- Manuela Ferracin,
- Cristina Ivan,
- Linda Fabris,
- Ramana V. Davuluri,
- Zhiyi Guo,
- Maria Angelica Cortez,
- Xinna Zhang,
- Lu Chen,
- Shuxing Zhang,
- Cecilia Fernandez-Cymering,
- Leng Han,
- Silvia Carloni,
- Samanta Salvi,
- Hui Ling,
- Mariam Murtadha,
- Paolo Neviani,
- Barbara J. Gitlitz,
- Ite A. Laird-Offringa,
- Patrick Nana-Sinkam,
- Massimo Negrini,
- Han Liang,
- Dino Amadori,
- Amelia Cimmino,
- George A. Calin,
- Muller Fabbri
Affiliations
- Ivan Vannini
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCS, Gene Therapy Unit
- Petra M. Wise
- Departments of Pediatrics and Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Children’s Center for Cancer and Blood Diseases and The Saban Research Institute, Children’s Hospital Los Angeles
- Kishore B. Challagundla
- Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center
- Meropi Plousiou
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCS, Gene Therapy Unit
- Mirco Raffini
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCS, Gene Therapy Unit
- Erika Bandini
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCS, Gene Therapy Unit
- Francesca Fanini
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCS, Gene Therapy Unit
- Giorgia Paliaga
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCS, Gene Therapy Unit
- Melissa Crawford
- Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University
- Manuela Ferracin
- Department of Experimental, Diagnostic and Specialty Medicine—DIMES, University of Bologna
- Cristina Ivan
- Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Linda Fabris
- The Center for RNA Interference and Non-coding RNAs, The University of Texas MD Anderson Cancer Center
- Ramana V. Davuluri
- Departments of Preventive Medicine and Neurological Surgery, Northwestern University-Feinberg School of Medicine
- Zhiyi Guo
- Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Maria Angelica Cortez
- Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Xinna Zhang
- The Center for RNA Interference and Non-coding RNAs, The University of Texas MD Anderson Cancer Center
- Lu Chen
- Integrated Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Shuxing Zhang
- Integrated Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Cecilia Fernandez-Cymering
- Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University
- Leng Han
- Department of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Silvia Carloni
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCS, Biosciences Laboratory Unit
- Samanta Salvi
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCS, Biosciences Laboratory Unit
- Hui Ling
- Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Mariam Murtadha
- Departments of Pediatrics and Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Children’s Center for Cancer and Blood Diseases and The Saban Research Institute, Children’s Hospital Los Angeles
- Paolo Neviani
- Departments of Pediatrics and Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Children’s Center for Cancer and Blood Diseases and The Saban Research Institute, Children’s Hospital Los Angeles
- Barbara J. Gitlitz
- Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Ite A. Laird-Offringa
- Departments of Surgery and Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Patrick Nana-Sinkam
- Division of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University
- Massimo Negrini
- Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara
- Han Liang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Dino Amadori
- Department of Oncology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) S.r.l., IRCCS
- Amelia Cimmino
- Institute of Genetics and Biophysics, National Research Council
- George A. Calin
- Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Muller Fabbri
- Departments of Pediatrics and Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Children’s Center for Cancer and Blood Diseases and The Saban Research Institute, Children’s Hospital Los Angeles
- DOI
- https://doi.org/10.1038/s41467-017-01562-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
T-UCRs encode long non-coding RNAs implicated in human carcinogenesis, but the underlying mechanisms are poorly understood. Here, the authors identify uc.339 as an oncogene in lung cancer that is upregulated through the loss of TP53 and promotes Cyclin E activation by entrapping regulatory miRNAs.
