Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons

Ye Zhang; Tin Ki Tsang; Eric A. Bushong; Li-An Chu; Ann-Shyn Chiang; Mark H. Ellisman; Jürgen Reingruber; Chih-Ying Su

doi:10.1038/s41467-019-09346-z

Nature Communications (Apr 2019)

Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons

Ye Zhang,
Tin Ki Tsang,
Eric A. Bushong,
Li-An Chu,
Ann-Shyn Chiang,
Mark H. Ellisman,
Jürgen Reingruber,
Chih-Ying Su

Affiliations

Ye Zhang: Neurobiology Section, Division of Biological Sciences, University of California San Diego
Tin Ki Tsang: Neurobiology Section, Division of Biological Sciences, University of California San Diego
Eric A. Bushong: National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California San Diego
Li-An Chu: Brain Research Center, National Tsing Hua University
Ann-Shyn Chiang: Brain Research Center, National Tsing Hua University
Mark H. Ellisman: National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California San Diego
Jürgen Reingruber: Institut of Biology, École Normale Supérieure (IBENS)
Chih-Ying Su: Neurobiology Section, Division of Biological Sciences, University of California San Diego

DOI: https://doi.org/10.1038/s41467-019-09346-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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In Drosophila antenna, an unusual non-synaptic form of lateral inhibition occurs between subtypes of compartmentalized olfactory receptor neurons (ORNs). Here, authors show that direct electrical (ephaptic) interactions mediate lateral inhibition between ORNs, with physically larger ORNs dominating ephaptic interactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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