Nature Communications (Jan 2020)

Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis

  • Vikram Saini,
  • Krishna C. Chinta,
  • Vineel P. Reddy,
  • Joel N. Glasgow,
  • Asaf Stein,
  • Dirk A. Lamprecht,
  • Md. Aejazur Rahman,
  • Jared S. Mackenzie,
  • Barry E. Truebody,
  • John H. Adamson,
  • Tafara T. R. Kunota,
  • Shannon M. Bailey,
  • Douglas R. Moellering,
  • Jack R. Lancaster,
  • Adrie J. C. Steyn

DOI
https://doi.org/10.1038/s41467-019-14132-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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The importance of host-produced hydrogen sulfide (H2S) in microbial pathogenesis is poorly understood. Here, Saini et al. show that H2S alters Mycobacterium tuberculosis (Mtb) central metabolism, stimulates respiration to promote growth and TB disease, and upregulates the Dos regulon.