Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users

Beatrice Setnik; Veeraindar Goli; Naama Levy-Cooperman; Catherine Mills; Megan Shram; Ira Smith

doi:10.1155/2013/952082

Pain Research and Management (Jan 2013)

Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users

Beatrice Setnik,
Veeraindar Goli,
Naama Levy-Cooperman,
Catherine Mills,
Megan Shram,
Ira Smith

Affiliations

Beatrice Setnik: Pfizer Inc, Cary, USA
Veeraindar Goli: Pfizer Inc, Cary, USA
Naama Levy-Cooperman: INC Research, University of Toronto, Toronto, Ontario, Canada
Catherine Mills: INC Research, University of Toronto, Toronto, Ontario, Canada
Megan Shram: INC Research, University of Toronto, Toronto, Ontario, Canada
Ira Smith: INC Research, University of Toronto, Toronto, Ontario, Canada

DOI: https://doi.org/10.1155/2013/952082
Journal volume & issue: Vol. 18, no. 4
pp. e55 – e62

Abstract

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OBJECTIVE: To evaluate the pharmacodynamic (PD) effects of morphine sulfate and naltrexone hydrochloride extended-release (MSN) capsules compared with controlled-release morphine sulfate (MS) and placebo when crushed and administered intranasally.

Published in Pain Research and Management

ISSN: 1203-6765 (Print); 1918-1523 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://onlinelibrary.wiley.com/journal/7040

About the journal