Frontiers in Cardiovascular Medicine (Dec 2020)
Role of Exosomal miRNAs in Heart Failure
- Ruicong Xue,
- Ruicong Xue,
- Ruicong Xue,
- Weiping Tan,
- Yuzhong Wu,
- Yuzhong Wu,
- Yuzhong Wu,
- Bin Dong,
- Bin Dong,
- Bin Dong,
- Zengshuo Xie,
- Zengshuo Xie,
- Zengshuo Xie,
- Peisen Huang,
- Peisen Huang,
- Peisen Huang,
- Jiangui He,
- Jiangui He,
- Jiangui He,
- Yugang Dong,
- Yugang Dong,
- Yugang Dong,
- Chen Liu,
- Chen Liu,
- Chen Liu
Affiliations
- Ruicong Xue
- Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Ruicong Xue
- NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
- Ruicong Xue
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Weiping Tan
- Department of Respiratory, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Yuzhong Wu
- Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Yuzhong Wu
- NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
- Yuzhong Wu
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Bin Dong
- Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Bin Dong
- NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
- Bin Dong
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Zengshuo Xie
- Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Zengshuo Xie
- NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
- Zengshuo Xie
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Peisen Huang
- Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Peisen Huang
- NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
- Peisen Huang
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jiangui He
- Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Jiangui He
- NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
- Jiangui He
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Yugang Dong
- Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Yugang Dong
- NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
- Yugang Dong
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Chen Liu
- Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Chen Liu
- NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
- Chen Liu
- National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- DOI
- https://doi.org/10.3389/fcvm.2020.592412
- Journal volume & issue
-
Vol. 7
Abstract
Heart failure is the terminal outcome of the majority of cardiovascular diseases, which lacks specific diagnostic biomarkers and therapeutic targets. It contributes to most of cardiovascular hospitalizations and death despite of the current therapy. Therefore, it is important to explore potential molecules improving the diagnosis and treatment of heart failure. MicroRNAs (miRNAs) are small non-coding RNAs that have been reported to be involved in regulating processes of heart failure. After the discovery of miRNAs in exosomes, the subcellular distribution analysis of miRNAs is raising researchers' attention. Growing evidence demonstrates that exosomal miRNAs may be promising diagnostic and therapeutic molecules for heart failure. This review summarizes the role of exosomal miRNAs in heart failure in the prospect of molecular and clinical researches.
Keywords
