MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

Israel Salguero; Rimma Belotserkovskaya; Julia Coates; Matylda Sczaniecka-Clift; Mukerrem Demir; Satpal Jhujh; Marcus D. Wilson; Stephen P. Jackson

doi:10.1038/s41467-019-12929-5

Nature Communications (Nov 2019)

MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

Israel Salguero,
Rimma Belotserkovskaya,
Julia Coates,
Matylda Sczaniecka-Clift,
Mukerrem Demir,
Satpal Jhujh,
Marcus D. Wilson,
Stephen P. Jackson

Affiliations

Israel Salguero: Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge
Rimma Belotserkovskaya: Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge
Julia Coates: Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge
Matylda Sczaniecka-Clift: Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge
Mukerrem Demir: Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge
Satpal Jhujh: Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge
Marcus D. Wilson: Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building
Stephen P. Jackson: Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge

DOI: https://doi.org/10.1038/s41467-019-12929-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

MDC1 and H2AX interact and accumulate at sites of DNA damage, functioning to recruit additional factors involved in the repair process. Here the authors uncover a function for MDC1 that is independent of the presence of H2AX and is mediated through its PST-repeat region.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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