Macro- and Microscopic Study of the Effect of 2-Phenyl-3-Carbethoxy-4-Dimethylaminomethyl-5-Hydroxybenzofuran Hydrochloride (Vinboron) on the Gastrotoxicity of Ibuprofen in Experimental Rheumatoid Arthritis in Rats

Abstract

It is known that besides a wide range of therapeutic effects, non-steroidal anti-inflammatory drugs have side effects such as gastroduodenotoxicity, hepatotoxicity, cardiotoxicity, nephrotoxicity, hematotoxicity, allergenicity, neurotoxicity, and others. We have proposed the use of Ukrainian antispasmodics with polytropic pharmacological properties of vinoboron in order to prevent ulcerogenic action of ibuprofen. The conducted study showed that the combined use of ibuprofen and vinoboron led to a weakening of the signs of gastrotoxicity of this antiflossistics. This was indicated by a significantly lower degree of lesion of the mucous membrane of the stomach - the ulcerous index was almost 10 times smaller than on the background of monotherapy and was, respectively, 0.10 and 0.97. The increase in body weight in rats with experimental rheumatoid arthritis in the 28th day of experiment with the combined use of ibuprofen and vinoboron was twice as high as that of animals in the monotherapy group and was 16.3 ± 3.19%, respectively (95% CI: 10.0-22.5 %) relative to 1 day of the experiment. The stomach ulcers were noted only in 14.3% of animals, which is three times lower than on the background of ibuprofen monotherapy.

Keywords

• vinoborone
• ibuprofen
• ulcerogenicity
• mucous membrane of the stomach
• non-steroidal anti-inflammatory drugs