Antimicrobial Drugs and Community–acquired Clostridium difficile–associated Disease, UK

Abstract

In a population-based case-control study of community-acquired Clostridium difficile–associated disease (CDAD), we matched 1,233 cases to 12,330 controls. CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agent did not affect risk for CDAD after 6 months.

Keywords

• Clostridium difficile–associated disease
• antimicrobial agents
• fluoroquinolones
• risk factors
• epidemiology
• dispatch