A Reviw of Effectiveness of Red betel Leaves (Piper crocatum) as Antihyperglysemic Activities

Abstract

In Indonesia, diabetes is third among the leading causes of death. Elevated blood sugar (hyperglycemia) is one of the clinical features of the disease. Indonesia has abundant potential herbal plants. The red betel leaf is one of the promising herbal plants (Piper crocatum). Alkaloids, saponins, tannins, and flavonoids are among the phytochemical components found in red betel leaf. This study was used as a medium of renewable information that was supported from several previous reference sources strengthening evidence of the benefits obtained from red betel leaf as an antihyperglycemic agent. The study uses a literature review method using journal database platforms such as Google Scholar, Pubmed, and ScienceDirect as search engines for journals related to this article. The potential activity of red betel leaf as an antihyperglycemic drug which can lower blood glucose was discovered from the findings of the numerous journal sources and related studies. Red betel leaf contains flavonoid compounds that are antioxidants. Antioxidants can bind to hydroxyl radicals that harm the pancreatic cells of the islets of Langerhans, allowing these substances to activate insulin activity and treat diseases like gout, cancer, hypertension, and diabetes. Red betel leaf has an effective candidate compound has the potential to be used as an antihyperglycemic agent to lower blood glucose.

Keywords

• antihyperglycemic
• bioactivity
• piper crocatum
• potency