Proteomics appending a complementary dimension to precision oncotherapy

Zhaokai Zhou; Ruiqi Zhang; Aoyang Zhou; Jinxiang Lv; Shuang Chen; Haijiao Zou; Ge Zhang; Ting Lin; Zhan Wang; Yuyuan Zhang; Siyuan Weng; Xinwei Han; Zaoqu Liu

Computational and Structural Biotechnology Journal (Dec 2024)

Proteomics appending a complementary dimension to precision oncotherapy

Zhaokai Zhou,
Ruiqi Zhang,
Aoyang Zhou,
Jinxiang Lv,
Shuang Chen,
Haijiao Zou,
Ge Zhang,
Ting Lin,
Zhan Wang,
Yuyuan Zhang,
Siyuan Weng,
Xinwei Han,
Zaoqu Liu

Affiliations

Zhaokai Zhou: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan 450052, China
Ruiqi Zhang: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Aoyang Zhou: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Jinxiang Lv: Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Shuang Chen: Center of Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Haijiao Zou: Center of Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Ge Zhang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Ting Lin: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Zhan Wang: Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan 450052, China
Yuyuan Zhang: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Siyuan Weng: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Xinwei Han: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Interventional Institute of Zhengzhou University, Zhengzhou, Henan 450052, China; Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan 450052, China; Corresponding authors at: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Zaoqu Liu: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Interventional Institute of Zhengzhou University, Zhengzhou, Henan 450052, China; Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan 450052, China; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; Corresponding authors at: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Journal volume & issue: Vol. 23
pp. 1725 – 1739

Abstract

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Recent advances in high-throughput proteomic profiling technologies have facilitated the precise quantification of numerous proteins across multiple specimens concurrently. Researchers have the opportunity to comprehensively analyze the molecular signatures in plentiful medical specimens or disease pattern cell lines. Along with advances in data analysis and integration, proteomics data could be efficiently consolidated and employed to recognize precise elementary molecular mechanisms and decode individual biomarkers, guiding the precision treatment of tumors. Herein, we review a broad array of proteomics technologies and the progress and methods for the integration of proteomics data and further discuss how to better merge proteomics in precision medicine and clinical settings.

Published in Computational and Structural Biotechnology Journal

ISSN: 2001-0370 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Chemical technology: Biotechnology
Website: https://www.journals.elsevier.com/computational-and-structural-biotechnology-journal

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