Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish

Julia Y. Kam; Elinor Hortle; Elizabeth Krogman; Sherridan E. Warner; Kathryn Wright; Kaiming Luo; Tina Cheng; Pradeep Manuneedhi Cholan; Kazu Kikuchi; James A. Triccas; Warwick J. Britton; Matt D. Johansen; Laurent Kremer; Stefan H. Oehlers

doi:10.1038/s41467-022-28638-5

Nature Communications (Feb 2022)

Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish

Julia Y. Kam,
Elinor Hortle,
Elizabeth Krogman,
Sherridan E. Warner,
Kathryn Wright,
Kaiming Luo,
Tina Cheng,
Pradeep Manuneedhi Cholan,
Kazu Kikuchi,
James A. Triccas,
Warwick J. Britton,
Matt D. Johansen,
Laurent Kremer,
Stefan H. Oehlers

Affiliations

Julia Y. Kam: Tuberculosis Research Program at the Centenary Institute, The University of Sydney
Elinor Hortle: Tuberculosis Research Program at the Centenary Institute, The University of Sydney
Elizabeth Krogman: Tuberculosis Research Program at the Centenary Institute, The University of Sydney
Sherridan E. Warner: Tuberculosis Research Program at the Centenary Institute, The University of Sydney
Kathryn Wright: Tuberculosis Research Program at the Centenary Institute, The University of Sydney
Kaiming Luo: Tuberculosis Research Program at the Centenary Institute, The University of Sydney
Tina Cheng: Tuberculosis Research Program at the Centenary Institute, The University of Sydney
Pradeep Manuneedhi Cholan: Tuberculosis Research Program at the Centenary Institute, The University of Sydney
Kazu Kikuchi: Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute
James A. Triccas: The University of Sydney, Faculty of Medicine and Health & Marie Bashir Institute
Warwick J. Britton: Tuberculosis Research Program at the Centenary Institute, The University of Sydney
Matt D. Johansen: Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier
Laurent Kremer: Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier
Stefan H. Oehlers: Tuberculosis Research Program at the Centenary Institute, The University of Sydney

DOI: https://doi.org/10.1038/s41467-022-28638-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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The pathogen Mycobacterium abscessus can switch from a smooth colony form (S) into a highly inflammatory, rough colony form (R) during infection. Here, Kam et al. use an adult zebrafish model of M. abscessus chronic infection to illustrate differences in the immunopathogenesis induced by R and S variants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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