Haematologica (May 2007)

ALK-mediated Na+/H+ exchanger-dependent intracellular alkalinization: does it matter for oncogenesis?

  • Francesco Turturro,
  • Michael Driscoll,
  • Ellen Friday,
  • Tomas Welbourne

DOI
https://doi.org/10.3324/haematol.10923
Journal volume & issue
Vol. 92, no. 5

Abstract

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In this study we investigated the relevance of the oncogenic protein NPM-ALK in regulating cellular pH (pHi) through the modulation of Na+/H+ exchanger 1 (NHE1)-activity and the consequences of pHi pharmacological manipulation in cells expressing NPM-ALK.