Nature Communications (Sep 2020)
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
- David H. Peng,
- Bertha Leticia Rodriguez,
- Lixia Diao,
- Limo Chen,
- Jing Wang,
- Lauren A. Byers,
- Ying Wei,
- Harold A. Chapman,
- Mitsuo Yamauchi,
- Carmen Behrens,
- Gabriela Raso,
- Luisa Maren Solis Soto,
- Edwin Roger Parra Cuentes,
- Ignacio I. Wistuba,
- Jonathan M. Kurie,
- Don L. Gibbons
Affiliations
- David H. Peng
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Bertha Leticia Rodriguez
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Lixia Diao
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Limo Chen
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jing Wang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Lauren A. Byers
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Ying Wei
- Department of Medicine, UCSF Cardiovascular Research Institute
- Harold A. Chapman
- Department of Medicine, UCSF Cardiovascular Research Institute
- Mitsuo Yamauchi
- Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill
- Carmen Behrens
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Gabriela Raso
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Luisa Maren Solis Soto
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Edwin Roger Parra Cuentes
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Ignacio I. Wistuba
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Jonathan M. Kurie
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Don L. Gibbons
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-18298-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaustion.
