Nature Communications (Apr 2020)
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
- Nicholas K. Vinckier,
- Nisha A. Patel,
- Ryan J. Geusz,
- Allen Wang,
- Jinzhao Wang,
- Ileana Matta,
- Austin R. Harrington,
- Matthew Wortham,
- Nichole Wetton,
- Jianxun Wang,
- Ulupi S. Jhala,
- Michael G. Rosenfeld,
- Christopher W. Benner,
- Hung-Ping Shih,
- Maike Sander
Affiliations
- Nicholas K. Vinckier
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- Nisha A. Patel
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- Ryan J. Geusz
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- Allen Wang
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- Jinzhao Wang
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- Ileana Matta
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- Austin R. Harrington
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- Matthew Wortham
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- Nichole Wetton
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- Jianxun Wang
- Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego
- Ulupi S. Jhala
- Department of Pediatrics and Pediatric Diabetes Research Center, University of California, San Diego
- Michael G. Rosenfeld
- Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego
- Christopher W. Benner
- Department of Cellular & Molecular Medicine, University of California, San Diego
- Hung-Ping Shih
- Department of Translational Research & Cellular Therapeutics, Diabetes & Metabolism Research Institute, City of Hope
- Maike Sander
- Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego
- DOI
- https://doi.org/10.1038/s41467-020-16017-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers respond to extracellular signals, namely retinoic acid.
