Nature Communications (Apr 2020)

TNIK signaling imprints CD8+ T cell memory formation early after priming

  • Carla A. Jaeger-Ruckstuhl,
  • Magdalena Hinterbrandner,
  • Sabine Höpner,
  • Colin E. Correnti,
  • Ursina Lüthi,
  • Olivier Friedli,
  • Stefan Freigang,
  • Mohamad F. Al Sayed,
  • Elias D. Bührer,
  • Michael A. Amrein,
  • Christian M. Schürch,
  • Ramin Radpour,
  • Carsten Riether,
  • Adrian F. Ochsenbein

DOI
https://doi.org/10.1038/s41467-020-15413-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Coordinate expression of multiple factors play critical roles in the regulation between effector and memory CD8+ T cell differentiation. Here the authors show upon acute viral infection TNIK is critically required as a regulator of effector and memory T cell differentiation.