Nature Communications (May 2022)
Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice
- Mathew Van de Pette,
- Andrew Dimond,
- António M. Galvão,
- Steven J. Millership,
- Wilson To,
- Chiara Prodani,
- Gráinne McNamara,
- Ludovica Bruno,
- Alessandro Sardini,
- Zoe Webster,
- James McGinty,
- Paul M. W. French,
- Anthony G. Uren,
- Juan Castillo-Fernandez,
- William Watkinson,
- Anne C. Ferguson-Smith,
- Matthias Merkenschlager,
- Rosalind M. John,
- Gavin Kelsey,
- Amanda G. Fisher
Affiliations
- Mathew Van de Pette
- Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- Andrew Dimond
- Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- António M. Galvão
- Epigenetics Programme, The Babraham Institute
- Steven J. Millership
- Department of Medicine, Imperial College London, Hammersmith Hospital Campus
- Wilson To
- Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- Chiara Prodani
- Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- Gráinne McNamara
- Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- Ludovica Bruno
- Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- Alessandro Sardini
- Whole Animal Physiology and Imaging, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- Zoe Webster
- Transgenics and Embryonic Stem Cell Laboratory, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- James McGinty
- Photonics Group, Department of Physics, Imperial College London, South Kensington Campus
- Paul M. W. French
- Photonics Group, Department of Physics, Imperial College London, South Kensington Campus
- Anthony G. Uren
- Cancer Genomics Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- Juan Castillo-Fernandez
- Epigenetics Programme, The Babraham Institute
- William Watkinson
- Department of Genetics, University of Cambridge, Downing Street
- Anne C. Ferguson-Smith
- Department of Genetics, University of Cambridge, Downing Street
- Matthias Merkenschlager
- Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- Rosalind M. John
- Cardiff School of Biosciences, Cardiff University
- Gavin Kelsey
- Epigenetics Programme, The Babraham Institute
- Amanda G. Fisher
- Lymphocyte Development & Epigenetic Memory Groups, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus
- DOI
- https://doi.org/10.1038/s41467-022-30022-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Here the authors show that a high-fat diet in pregnant mice can release silencing of the imprinted Dlk1 locus in multiple generations of offspring. They found that this occurs via changes in microRNA expression at the locus of interest, as well as transcriptional changes across the genome, in the developing oocytes.
