Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

Hadir Marei; Alejandro Carpy; Anna Woroniuk; Claire Vennin; Gavin White; Paul Timpson; Boris Macek; Angeliki Malliri

doi:10.1038/ncomms10664

Nature Communications (Feb 2016)

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

Hadir Marei,
Alejandro Carpy,
Anna Woroniuk,
Claire Vennin,
Gavin White,
Paul Timpson,
Boris Macek,
Angeliki Malliri

Affiliations

Hadir Marei: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester
Alejandro Carpy: Proteome Center Tuebingen, Interfaculty Institute for Cell Biology, University of Tuebingen
Anna Woroniuk: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester
Claire Vennin: Invasion and Metastasis Group, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Faculty of Medicine, St Vincent’s Clinical School, University of New South Wales
Gavin White: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester
Paul Timpson: Invasion and Metastasis Group, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Faculty of Medicine, St Vincent’s Clinical School, University of New South Wales
Boris Macek: Proteome Center Tuebingen, Interfaculty Institute for Cell Biology, University of Tuebingen
Angeliki Malliri: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester

DOI: https://doi.org/10.1038/ncomms10664
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the Rac1 interactome to determine the downstream phenotype.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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