Nature Communications (Jun 2019)
SETD1A protects from senescence through regulation of the mitotic gene expression program
- Ken Tajima,
- Satoru Matsuda,
- Toshifumi Yae,
- Benjamin J. Drapkin,
- Robert Morris,
- Myriam Boukhali,
- Kira Niederhoffer,
- Valentine Comaills,
- Taronish Dubash,
- Linda Nieman,
- Hongshan Guo,
- Neelima K. C. Magnus,
- Nick Dyson,
- Toshihiro Shioda,
- Wilhelm Haas,
- Daniel A. Haber,
- Shyamala Maheswaran
Affiliations
- Ken Tajima
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Satoru Matsuda
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Toshifumi Yae
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Benjamin J. Drapkin
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Robert Morris
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Myriam Boukhali
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Kira Niederhoffer
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Valentine Comaills
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Taronish Dubash
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Linda Nieman
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Hongshan Guo
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Neelima K. C. Magnus
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Nick Dyson
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Toshihiro Shioda
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Wilhelm Haas
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Daniel A. Haber
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Shyamala Maheswaran
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-10786-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence.
