Nature Communications (Jul 2019)
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
- Swagata Halder,
- Ignacio Torrecilla,
- Martin D. Burkhalter,
- Marta Popović,
- John Fielden,
- Bruno Vaz,
- Judith Oehler,
- Domenic Pilger,
- Davor Lessel,
- Katherine Wiseman,
- Abhay Narayan Singh,
- Iolanda Vendrell,
- Roman Fischer,
- Melanie Philipp,
- Kristijan Ramadan
Affiliations
- Swagata Halder
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- Ignacio Torrecilla
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- Martin D. Burkhalter
- Institute of Biochemistry and Molecular Biology, Ulm University
- Marta Popović
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- John Fielden
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- Bruno Vaz
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- Judith Oehler
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- Domenic Pilger
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- Davor Lessel
- Institute of Human Genetics, University Medical Center Hamburg-Eppendorf
- Katherine Wiseman
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- Abhay Narayan Singh
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- Iolanda Vendrell
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- Roman Fischer
- TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
- Melanie Philipp
- Institute of Biochemistry and Molecular Biology, Ulm University
- Kristijan Ramadan
- Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-019-11095-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.
