Reduction of the Double Bond of 6‑Arylvinyl-1,2,4-trioxanes Leads to a Remarkable Increase in Their Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii nigeriensis in a Swiss Mice Model

• Mohammad Hassam,
• Ajit Shankar Singh,
• Dinesh Kumar Yadav,
• Chandan Singh,
• Sunil K. Puri,
• Ved Prakash Verma

Affiliations

Mohammad Hassam

Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India

Ajit Shankar Singh

Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India

Dinesh Kumar Yadav

Department of Chemistry, Mohanlal Sukhadia University, Udaipur, India

Chandan Singh

Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India

Sunil K. Puri

Parasitology Division, CSIR-Central Drug Research Institute, Lucknow, India

Ved Prakash Verma

Department of Chemistry, Banasthali University, Banasthali Newai, Rajasthan, India