Journal of Veterinary Medical Research (Jun 2010)
Some pharmacological studies of cephradine in broilers
Abstract
The pharmacokinetic aspects of cephradine were studied after intravenous (IV), intramuscular (IM), subcutaneous (SC) and oral administration of a single dose of 50 mg kg-1 b.wt. in chickens. Tissue distribution and residues of cephradine after repeated oral administration for 5 consecutive days were also estimated. After IV injection of cephradine in a dose of 50 mg kg-1 b.wt., the serum concentration time curves were best described by a two compartment-open model. The drug was rapidly distributed with a distribution half-life (t0.5(α)) of 0.120 h and apparent volume of distribution (Vdss) was 2.187 L kg-1. The drug was rapidly eliminated with a half-life of elimination (t0.5(β)) of 1.047 h and the body clearance (ClB) was 2.35 L kg-1 h-1. The drug was rapidly absorbed after IM, SC and oral administration as indicated by short half-lives of absorption (t0.5(ab)) of 0.154, 0.364 and 0.65 h., respectively. While the elimination half-lives (t0.5(el)) and systemic bioavailabilities were 0.859, 2.652, 1.74 h and 59.386, 84.5, 97.97 %, respectively. Repeated oral administration of cephradine (50 mg kg-1 b.wt twice daily) for 5 consecutive days caused no change in serum enzyme activities of ALT and AST but induced a significant increase in serum uric acid concentration at 72 to 120 hours post administration.
