Early onset androgenic alopecia as the male phenotypic equivalent of polycystic ovarian syndrome is associated in high oxidative stress

Abstract

The genetic component of Polycystic ovarian syndrome (PCOS) proved to play an important role in its etiology. Early androgenetic alopecia (EAGA) is widely accepted as its male equivalent of PCOS if it starts before age of 30. In this study, we aimed to investigate metabolic and oxidative stress parameters of men with EAGA and compare them with healthy age-matched controls. Fasting glucose, fasting insulin, homocysteine, serum malondialdehyde (MDA), total antioxidant capacity (TAC), folic acid, and vitamin B12 were measured from the blood samples of thirty men with EAGA and 30 controls. Homeostasis model assessment (HOMA) results were used for the marker of insulin sensitivity. Alopecia classification was made by using the scale of Hamilton with Norwood modification. We demonstrated a significantly lower TAC activity (p [Med-Science 2021; 10(2.000): 609-13]

Keywords

• early onset androgenetic alopecia
• polycystic ovary syndrome
• insulin resistance
• oxidative stress