Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia

Abstract

Ataxia telangiectasia (AT) is a rare autosomal recessive primary immunodeficiency disorder (PID) resulting from a mutation in the ATM gene, which is involved in DNA repair. We describe the case of a young girl with cutaneous granulomas that developed after childhood vaccinations. Immunohistochemistry revealed granulomas induced by the rubella virus vaccine. This finding raises the question of live rubella vaccine strains safety in immunocompromised children.

Keywords

• Ataxia telangiectasia
• immunodeficiency
• rubella
• granuloma
• vaccine