Nature Communications (Jul 2022)

Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex

  • Nicholas M. Timme,
  • Baofeng Ma,
  • David Linsenbardt,
  • Ethan Cornwell,
  • Taylor Galbari,
  • Christopher C. Lapish

DOI
https://doi.org/10.1038/s41467-022-31731-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Compulsive alcohol drinking is a core feature of alcohol use disorder. Here the authors find that in rodents, neural signals in a key decision-making brain region (dmPFC) shift from behavioral control to alcohol seeking during compulsive alcohol drinking behaviour.