Nature Communications (Jan 2016)
A mouse model for a partially inactive obesity-associated human MC3R variant
- Bonggi Lee,
- Jashin Koo,
- Joo Yun Jun,
- Oksana Gavrilova,
- Yongjun Lee,
- Arnold Y. Seo,
- Dezmond C. Taylor-Douglas,
- Diane C. Adler-Wailes,
- Faye Chen,
- Ryan Gardner,
- Dimitri Koutzoumis,
- Roya Sherafat Kazemzadeh,
- Robin B. Roberson,
- Jack A. Yanovski
Affiliations
- Bonggi Lee
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Jashin Koo
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Joo Yun Jun
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Oksana Gavrilova
- Mouse Metabolism Core Laboratory, NIDDK, National Institutes of Health, 10 Center Drive
- Yongjun Lee
- Heritable Disorders Branch, NICHD, National Institutes of Health, 10 Center Drive
- Arnold Y. Seo
- Cell Biology and Metabolism Program, NICHD, National Institutes of Health
- Dezmond C. Taylor-Douglas
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Diane C. Adler-Wailes
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Faye Chen
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Ryan Gardner
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Dimitri Koutzoumis
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Roya Sherafat Kazemzadeh
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Robin B. Roberson
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- Jack A. Yanovski
- Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive
- DOI
- https://doi.org/10.1038/ncomms10522
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
The melanocortin receptor, MC3R, regulates organismal energy homeostasis. Here, Lee et al. create knock-in mice with the a mutated version of the human MC3R receptor found in obese children, and show these mice have more fat and smaller bone, yet are by and large metabolically healthy.
