The Egyptian Journal of Radiology and Nuclear Medicine (Sep 2024)

Inter-observer reliability and predictive values of triphasic computed tomography for microvascular invasion in hepatocellular carcinoma

  • Gehad A. Saleh,
  • Fatmaelzahraa Abdelfattah Denewar,
  • Khadiga M. Ali,
  • Marwa Saleh,
  • Mahmoud Abdelwahab Ali,
  • Ahmed Shehta,
  • Manar Mansour

DOI
https://doi.org/10.1186/s43055-024-01354-4
Journal volume & issue
Vol. 55, no. 1
pp. 1 – 12

Abstract

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Abstract Background Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor globally and a leading cause of mortality in cirrhotic patients. Our study aimed to estimate the diagnostic performance of triphasic CT and inter-observer reliability in the preoperative detection of microvascular invasion (MVI) in HCC. Two independent radiologists accomplished a retrospective analysis for 99 patients with HCC to assess the CT features for MVI in each lesion. Postoperative histopathology was considered the gold standard. Results Multivariate regression analysis revealed that incomplete or absent tumor capsules, presence of TTPV, and absence of hypodense halo were statistically significant independent predictors of MVI. There was excellent agreement among observers in evaluating peritumoral enhancement, identifying intratumoral arteries, hypodense halo, TTPV, and macrovascular invasion. Also, our results revealed moderate agreement in assessing the tumor margin and tumor capsule. Conclusion Triphasic CT features of MVI are reliable imaging predictors that may be helpful for standard preoperative interpretation of HCC.

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