PLoS ONE (Nov 2010)

Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.

  • Daouda Sissoko,
  • Khaled Ezzedine,
  • Claude Giry,
  • Amrat Moendandzé,
  • Tinne Lernout,
  • Eric D'Ortenzio,
  • François Pettinelli,
  • Denis Malvy

DOI
https://doi.org/10.1371/journal.pone.0014141
Journal volume & issue
Vol. 5, no. 11
p. e14141

Abstract

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BackgroundAlthough Dengue virus (DENV) circulation had been documented in neighbouring South-western Indian Ocean Islands, its presence in Mayotte is poorly characterised. To address this issue, we aimed to assess the seroprevalence of dengue IgG antibodies (DENV-IgG Ab) among the population and to investigate potential associations with individual and household characteristics.Methods/principal findingsIn November-December 2006 we conducted a cross-sectional serologic survey in Mayotte among 1,154 inhabitants aged≥2 years by using a multistage cluster random sampling method. The overall prevalence of DENV-specific IgG antibodies (ELISA) was 22.73% (95% CI, 18.16-27.31). The age-specific seroprevalence increased with age (χ2 for trend=11.86, PConclusionsThese findings document substantial prior exposure of the population of Mayotte to DENV and highlight the risk of severe illness due to the possibility of sequential DENV infections. Further investigations characterizing current DENV circulation patterns and associated serotypes are needed.