Nature Communications (Aug 2021)
Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
- Yifat Ofir-Birin,
- Hila Ben Ami Pilo,
- Abel Cruz Camacho,
- Ariel Rudik,
- Anna Rivkin,
- Or-Yam Revach,
- Netta Nir,
- Tal Block Tamin,
- Paula Abou Karam,
- Edo Kiper,
- Yoav Peleg,
- Reinat Nevo,
- Aryeh Solomon,
- Tal Havkin-Solomon,
- Alicia Rojas,
- Ron Rotkopf,
- Ziv Porat,
- Dror Avni,
- Eli Schwartz,
- Thomas Zillinger,
- Gunther Hartmann,
- Antonella Di Pizio,
- Neils Ben Quashie,
- Rivka Dikstein,
- Motti Gerlic,
- Ana Claudia Torrecilhas,
- Carmit Levy,
- Esther N. M. Nolte-‘t Hoen,
- Andrew G. Bowie,
- Neta Regev-Rudzki
Affiliations
- Yifat Ofir-Birin
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Hila Ben Ami Pilo
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Abel Cruz Camacho
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Ariel Rudik
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Anna Rivkin
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Or-Yam Revach
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Netta Nir
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Tal Block Tamin
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Paula Abou Karam
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Edo Kiper
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Yoav Peleg
- Structural Proteomics Unit, Department of Life Sciences Core Facilities (LSCF), Weizmann Institute of Science
- Reinat Nevo
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Aryeh Solomon
- Department of Biological Regulation, Weizmann Institute of Science
- Tal Havkin-Solomon
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Alicia Rojas
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Ron Rotkopf
- Department of Life Sciences Core Facilities, Weizmann Institute of Science
- Ziv Porat
- Flow Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of Science
- Dror Avni
- The Institute of Geographic Medicine and Tropical Diseases and the Laboratory for Tropical Diseases Research, Sheba Medical Center
- Eli Schwartz
- The Institute of Geographic Medicine and Tropical Diseases and the Laboratory for Tropical Diseases Research, Sheba Medical Center
- Thomas Zillinger
- Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn
- Gunther Hartmann
- Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn
- Antonella Di Pizio
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Technical University of Munich
- Neils Ben Quashie
- Epidemiology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana
- Rivka Dikstein
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- Motti Gerlic
- Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University
- Ana Claudia Torrecilhas
- Department of Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP
- Carmit Levy
- Department of Human Genetics and Biochemistry, Tel Aviv University
- Esther N. M. Nolte-‘t Hoen
- Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Andrew G. Bowie
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Neta Regev-Rudzki
- Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-021-24997-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The chemokine CXCL10 is associated with pathogenesis of cerebral malaria in Plasmodium falciparum infection. Here the authors show that P. falciparum produces extracellular vesicles laden with RNAs that are taken up by monocytes resulting in a RIG-I and HUR-1 mediated mechanism of inhibition of CXCL10 protein translation.
