Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway

Nobuaki Ishihama; Seung-won Choi; Yoshiteru Noutoshi; Ivana Saska; Shuta Asai; Kaori Takizawa; Sheng Yang He; Hiroyuki Osada; Ken Shirasu

doi:10.1038/s41467-021-27489-w

Nature Communications (Dec 2021)

Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway

Nobuaki Ishihama,
Seung-won Choi,
Yoshiteru Noutoshi,
Ivana Saska,
Shuta Asai,
Kaori Takizawa,
Sheng Yang He,
Hiroyuki Osada,
Ken Shirasu

Affiliations

Nobuaki Ishihama: Plant Immunity Research Group, RIKEN Center for Sustainable Resource Science
Seung-won Choi: Plant Immunity Research Group, RIKEN Center for Sustainable Resource Science
Yoshiteru Noutoshi: Graduate School of Environmental and Life Science, Okayama University
Ivana Saska: Plant Immunity Research Group, RIKEN Center for Sustainable Resource Science
Shuta Asai: Plant Immunity Research Group, RIKEN Center for Sustainable Resource Science
Kaori Takizawa: Plant Immunity Research Group, RIKEN Center for Sustainable Resource Science
Sheng Yang He: Department of Energy Plant Research Laboratory, Michigan State University
Hiroyuki Osada: Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science
Ken Shirasu: Plant Immunity Research Group, RIKEN Center for Sustainable Resource Science

DOI: https://doi.org/10.1038/s41467-021-27489-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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The plant defense hormone salicylic acid has structural similarity to oxicam-type non-steroidal antiinflammatories. Here the authors show oxicams, as well as endogenous salicylic acid, can alter cellular redox state and immune signaling without affecting the redox status of cysteines in NPR1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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