Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

Qinggang Dai; Siru Zhou; Peng Zhang; Xuhui Ma; Nayong Ha; Xiao Yang; Zhifeng Yu; Bing Fang; Lingyong Jiang

doi:10.1038/s41598-017-04422-0

Scientific Reports (Jun 2017)

Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

Qinggang Dai,
Siru Zhou,
Peng Zhang,
Xuhui Ma,
Nayong Ha,
Xiao Yang,
Zhifeng Yu,
Bing Fang,
Lingyong Jiang

Affiliations

Qinggang Dai: Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology
Siru Zhou: Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology
Peng Zhang: Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology
Xuhui Ma: Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology
Nayong Ha: Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology
Xiao Yang: Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology
Zhifeng Yu: Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine
Bing Fang: Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology
Lingyong Jiang: Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology

DOI: https://doi.org/10.1038/s41598-017-04422-0
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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Abstract As the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and is harmful to alveolar bone health under osteoporotic conditions remains to be answered. The present study aimed to clarify the influences of OTM on alveolar bone in osteoporotic rats. OTM was accelerated in ovariectomized (OVX) rats as a result of increased bone resorption in the pressure area. At the same time, anabolic bone formation was promoted in the tension area during OTM in OVX rats. Micro-CT analysis of alveolar bone revealed a decrease in BMD, BV/TV and Tb.Th. in the OTM group compared with that in non-OTM rats on day 21 of OTM, suggesting that OTM caused alveolar bone loss in OVX rats during OTM. However, the OTM-induced bone loss could be recovered 3 months after OTM in OVX rats. Thus, our findings suggest that increased osteogenesis may compensate for the increased bone resorption during and after OTM and enable effective accelerated OTM in OVX rats.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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