Case report: Occult Listeria monocytogenes invasion leading to prosthetic hip joint infection in a patient with rheumatoid arthritis taking tofacitinib

Chaowen Deng; Kelvin Hei-Yeung Chiu; Nan Lou; Fanfan Xing

doi:10.3389/fmed.2023.1322993

Frontiers in Medicine (Jan 2024)

Case report: Occult Listeria monocytogenes invasion leading to prosthetic hip joint infection in a patient with rheumatoid arthritis taking tofacitinib

Chaowen Deng,
Kelvin Hei-Yeung Chiu,
Nan Lou,
Fanfan Xing

Affiliations

Chaowen Deng: Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
Kelvin Hei-Yeung Chiu: Department of Microbiology, Queen Mary Hospital, Hong Kong, Hong Kong SAR, China
Nan Lou: Department of Orthopedics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
Fanfan Xing: Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China

DOI: https://doi.org/10.3389/fmed.2023.1322993
Journal volume & issue: Vol. 10

Abstract

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It has been suggested that targeted therapy may potentially increase the risk of listeriosis. However, no reported cases of Listeria monocytogenes prosthetic joint infection have been documented during Janus Kinase (JAK) pathway inhibitor use. Herein, we present a 70-year-old female with rheumatoid arthritis who had undergone bilateral hip joint replacement and subsequently developed Listeria monocytogenes prosthetic joint infection following tofacitinib therapy. We suggest that the use of tofacitinib may potentially heighten susceptibility to listeriosis in patients afflicted with rheumatoid arthritis.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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