Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Lin Xu; Lin Xu; Xuan-Lei Zhong; Xuan-Lei Zhong; Zhi-Chao Xi; Zhi-Chao Xi; Yang Li; Yang Li; Hong-Xi Xu

doi:10.3389/fmicb.2022.1025605

Frontiers in Microbiology (Oct 2022)

Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Lin Xu,
Lin Xu,
Xuan-Lei Zhong,
Xuan-Lei Zhong,
Zhi-Chao Xi,
Zhi-Chao Xi,
Yang Li,
Yang Li,
Hong-Xi Xu

Affiliations

Lin Xu: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Lin Xu: Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, China
Xuan-Lei Zhong: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Xuan-Lei Zhong: Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, China
Zhi-Chao Xi: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Zhi-Chao Xi: Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, China
Yang Li: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yang Li: Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, China
Hong-Xi Xu: Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fmicb.2022.1025605
Journal volume & issue: Vol. 13

Abstract

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Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natural compounds that inhibited ACV-resistant HSV infection and their mechanism of action.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

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