Impacts of Gadolinium-Based MRI contrast Agent on Hematological and Biochemical Tests for the Human Volunteers.

Abstract

Magnetic resonance imaging (MRI) Gadolinium-Containing contrast agents are used in combination with MRI in some situations. The effects of gadolinium-based MRI contrast agent (MAGNEVIST® Gadopentetate Dimeglumine Injection Bayer Standard 469 mg/ml (0.5 mmol/ml) on some hematological and biochemical tests for human male volunteers have been investigated. The study consisted of nine healthy individuals of human male volunteers; they were injected with intravenous (IV) contrast without being exposed to MRI. The cases are divided into four subgroups based on how long and how many times of blood samples were withdrawn after the intravenous (IV) contrast injection (9, 25, and 40 minutes). Blood samples were examined for twenty-seven hematological and biochemical parameters. The results proved that; after 9 min of injection with IV contrast, the WBCs count, LYM, MID%, and ALT decreased by 6%,6%, 4%, and 5%, respectively, and the concentration of GRA% and ESR increased by 5%. 25min after injection, concentrations of PLT increased significantly (P 0.05) by 4%, 5%, 7%, and 26%, respectively. After 40min of injections; MID, and MID% increased by 11% and 12%, respectively, and AST decreased by 4%. The maximum rise in ESR was increased by 31%. There was no substantial variation with time can be seen in electrolytes; Sodium (Na+), Potassium (K+), and Chloride (Cl-) under the effect of the intravenous contrast injection.

Keywords

• mri; contrast materials; hematological and biochemical tests; radiobiology